Evolutionary
Genomics and Bioinformatics (EGB) Laboratory
Tel: +91-11-25307-322 (Office),
-328 (
Fax: +91-11-25307-371
(Direct)
E-mail: egblab.nimr@gmail.com
The major focus of this laboratory is to
understand evolutionary interactions of malaria parasites-vectors-host at the
gene and genome level in the malaria triangle and use the information in
malaria control program of the country.
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To achieve these goals, we use genomics
and bioinformatics in an evolutionary perspective. All our current
research programs are based on scoring of Single Nucleotide Polymorphisms
(SNPs) both in putatively neutral genomic regions and of candidate genes of
interest followed by rigorous statistical analyses of genetic diversity data of
the SNPs under different population genetic and molecular evolutionary models
independently in malaria parasites, vectors and host.
Broadly, our current
research falls into following major projects
·
Gene
and genome diversity and evolution in Indian malaria parasites
·
Population
and evolutionary genomics of Indian malaria vectors
·
Evolutionary
genetics of immune system genes involved in malaria pathogenesis in Indian
humans
Publications
by the members of EGB Laboratory
·
Sharma M, Mohanty S, Tyagi S and Das A (2010) Comparative
and evolutionary genomics of malaria parasites. Proc Natl Acad Sci (
·
Sharma M, Dash AP and Das A (2010) Evolutionary genetic insights into Plasmodium falciparum functional genes. Parasitol
Res 106: 149-155.
·
Singh V, Mishra N, Awasthi G, Dash AP and Das A (2009) Why is it important to study malaria epidemiology in
India? Trends Parasitol 25: 452-457.
·
Awasthi G., Dash AP and Das A (2009) Evolutionary
insights into Duffy gene in mammalian taxa with comparative genetic analysis.
J Vect Borne Dis 46: 230-236.
·
Srivastava H, Dixit J, Dash AP and Das A (2009) Fine-scale evolutionary insights into Anopheles gambiae X chromosome.
J Biomed Sci Engg 2:
304-311.
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Raghavendra K, Niranjan Reddy BP, Dash AP and Das A (2009) Reanalysis
of rDNA-ITS2 region sequences of Anopheles cf. culicifacies ‘Bluchistan’
revealed conspecificity to A. dthali.
Curr Sci 97: 923-925.
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Das A, Sharma M, Gupta B and Dash AP (2009) Plasmodium falciparum and P. vivax: So similar yet very different. Parasitol
Res 105: 1169-1171.
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Awasthi G, Dash AP and Das A (2009) Characterization
and evolutionary analysis of human CD36 gene.
- Kar PK, Nagpal BN, Dua VK, Ghosh
SK, Raghavendra K, Bhatt RM, Anvikar A and Das A (2009) Molecular characterization of chikungunya virus from Andhra
Pradesh, India.
- Awasthi G, Singh S, Dash AP
and Das A (2008) Genetic characterization and evolutionary
inference of TNF-α with
computational analyses. Braz J Infect Dis 12: 374-379.
- Bajaj R, Mohanty S, Dash AP
and Das A (2008) Fine-scale genetic characterization of Plasmodium
falciparum chromosome 7 encompassing the antigenic var and the
drug-resistant pfcrt genes. J Genet 87: 59-64.
- Das A and Dash AP (2007) Evolutionary paradigm of drug-resistant malaria in
India. Trends Parasitol 23: 132-135.
- Thomas C, Shalini S,
Raghavendra N, Choudhury M, Verma A, Joshi H, Dash AP and Das A
(2007) Development of nuclear DNA markers for evolutionary
studies in Plasmodium falciparum. J Genet 86: 65-68.
- Das A, Bajaj R, Mohanty S and
Swain V (2007) Genetic diversity and evolutionary history of Plasmodium
falciparum and P. vivax. Curr Sci 92:
1516-1524.
Significant
Publication:
·
Das A. 1991. DNA fingerprinting in India. Nature 350: 387
Scientific Staff of the EGB Laboratory
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Aparup Das (Since December 2005)
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Academic Records: ·
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Ph. D. (Population
Genetics) Banaras
Hindu University, ·
M. Sc. (Zoology)
Utkal
University, ·
B. Sc. (Zoology
Hons.) Utkal University, Recent Awards and Achievements: ·
Overseas Associateship from the Department
of Biotechnology, Govt. of Research Interests: ·
Gene and genome diversity of malaria parasites ·
Population and evolutionary genomics of malaria vectors ·
Evolutionary genetics of host immune system Professional Activities: ·
Member, Editorial Board of the Journal of Genetics (2008 - till date) ·
Member, Editorial Committee of the Journal of Vector Borne
Diseases (2006 - till date) ·
Member, Editorial Board of the Journal
of Biomedical Science and Engineering (2009 – till date) ·
Editor, Global Journal of
Biotechnology (2006 - till date) ·
Editor, Global Journal of Molecular
Sciences (2006 - till date) ·
Editor, Plasmodium,
NIMR Newsletter (2006 - till date) |
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Gauri Awasthi (Since May
2007)
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Academic Records: ·
Post-M. Sc. research experience at NEHM and NIMR, ·
M.Sc. (Applied
Microbiology and Biotechnology), Banasthali Vidyapith, Rajasthan ·
B. Sc. (Biotechnology,
Hons.), Amity Research Interests: ·
Seeking new gene target (s) for chloroquine resistance in Indian Plasmodium
falciparum Recent Awards and Achievements: ·
International Travel Award from the Journal of Cell Sciences, ·
International Travel Award from the Boehringer Ingelheim Fonds, ·
Invited to work as an Independent Researcher at the ·
Second-best prize for poster presentation at the International
Conference of Vector and Vector-borne Diseases, Puri, 2008 |
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Hemlata Srivastava (Since June
2007)
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Academic Records: ·
Post -M. Sc. teaching experience at 10+2 level in ·
M.Sc.
(Biotechnology), Mahatma Gandhi Institute of Applied Sciences, Jaipur, ·
B. Sc.
(Life Sciences), Research Interests: ·
Evolutionary genetic studies of immune system genes in Indian Anopheles
minimus |
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Jyotsana
Dixit (Since June
2007)
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Academic Records: ·
Post-M.Phill research experiences at NIMR and at Centre for Advanced Studies in
Zoology (D.U.), ·
MPhill
(Reproductive Physiology) Centre for Advanced Studies in Zoology, ·
M.Sc.
(Zoology), ·
B. Sc.
(Zoology, Hons.), North Campus, Research
Interests: ·
Population structure and demography of Indian Anopheles minimus
with genomics and bioinformatic approaches |
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Meenu Sharma SRF, ICMR-Direct (Since Jan
2009)
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Academic Records: ·
Post -M. Sc. teaching experience at UG level in ·
M. Sc.
(Biochemistry), ·
B. Sc. (Life
Sciences), Research
Interests: ·
Estimation of genetic diversity in Erythrocyte binding antigenic
genes of Plasmodium falciparum |
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Bhavna Gupta (Since January
2008)
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Academic
Records: ·
Post-M.Sc. research experience at The
Energy and Resources Institute (TERI), ·
M.Sc. (Agriculture Biotechnology), Indira Gandhi Krishi
Vishwavidyalaya, ·
B. Sc. (Agriculture), Research
Interests: · Population genomics of Indian Plasmodium
vivax Recent
Awards and Achievements: ·
Qualified National Eligibility Test (NET) conducted by the Indian
Council of Medical Research (ICMR), |
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Naazneen Khan JRF,
ICMR-NET (Since
October 2008) |
Academic
Records: ·
M. Sc. (Biotechnology),
Jamia Millia Islamia, ·
B. Sc. (Biotechnology), Jamia Millia Islamia, Research
Interests: ·
Genetic diversity and Evolutionary history of an anti-malaria drug
detoxifying gene in Indian Humans. Recent
Awards and Achievements: ·
Qualified National Eligibility Test (NET) conducted by the Indian
Council of Medical Research (ICMR), |
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Suchi Tyagi RA, ICMR - Project (Since
November 2008) |
Academic
Records: ·
Post -M. Sc. research experience at NIMR, ·
M. Sc. (Bioinformatics),
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B. Sc.
(Botany, Hons.), Research Interests: ·
Evolutionary history of PTEX150 gene in Indian Plasmodium
falciparum. |
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Other
Staff of the EGB Laboratory
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Ms. Kamla Negi,
Laboratory
Technician
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Mr. Kumar
Vikram, Research Assistant
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Mr. Satveer
Singh, Field-cum-Laboratory
Attendant
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Mr. Sunil
Tyagi, Field-cum-Laboratory
Attendant
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Mr. Satyaveer
Sharma, Laboratory
Attendant (DW)
Important Information
for Project/Summer Trainee Applicants to the EGB Laboratory
Apply (by e-mail only) with a recent CV
and a brief outline of the proposed work you are interested to perform
in this laboratory (choose any one of the three broad areas indicated above)
CVs without the write-up will NOT be
considered in ANY CASE